Abstract
Hair loss is a common human scalp condition caused by chemotherapy, chronic diseases, and aging. Currently, it is estimated that approximately 50% of males and 15–30% of females experience hair loss issues. Minoxidil is considered a preferred treatment for hair loss in men and women. Nifedipine is effective in improving blood circulation and blood supply via its vasodilator action. To compare nifedipine and minoxidil in terms of their effect on stimulating hair growth using a mouse model. Fifteen female albino mice, aged 8 to 10 weeks, were randomly assigned to three groups of five mice each, all with shaved dorsal skin, for a 21-day experiment. Group 1 (untreated intact control) consisted of healthy mice that experienced the same conditions as the other groups without receiving any treatment. Group 2 (Positive control) contained mice that received a standard drug, minoxidil solution at a 2% concentration, administered topically once daily for 21 days. Group 3 included mice that received topical treatment with nifedipine gel (0.3% w/w) once daily for 21 days. Hair samples were collected on days 14 and 21. Nifedipine cream and standard minoxidil solution 2% increased hair growth when compared with an untreated control group, and the hair of the mice group treated with nifedipine cream on days 14 and 21 of the treatment course was significantly longer than all the other mouse groups treated with minoxidil solution 2%. The current study shows that nifedipine cream exhibits hair growth-promoting effects, with the best result being observed with the use of nifedipine topical cream in a strength of 0.3%.
Recommended Citation
Ahmed, Nihad Hussein; Salih, Rabei Abdullah; and Mekkey, Shereen M.
()
"A Comparative Study Examining the Effects of Nifedipine and Minoxidil on Stimulating Hair Growth Using a Mouse Model,"
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences: Vol. 4
:
Iss.
1
, Article 5.
Available at:
https://doi.org/10.62846/3006-5909.1042
