Abstract
Background: Oral administration is the most common and preferred route for drug delivery. Oral dispersible tablets (ODTs) are solid dosage forms that disintegrate into saliva without the need for water. Tizanidine is a centrally acting muscle relaxant used to manage spasticity from spinal or brain injuries. Preparing it as a flash (ODT) tablet may enhance patient compliance and potentially improve bioavailability by bypassing part of the first-pass metabolism. Methods: Six formulations of tizanidine flash tablets were developed using varying concentrations of mannitol (bulk-forming agent), glycine (to aid tablet collapse), and gelatin (matrix-forming agent). The formulations were evaluated for weight variation, friability, wetting time, disintegration time, and drug release. Results: All formulations complied with pharmacopeial standards for weight variation and friability (0.75–0.94%). Wetting times ranged from 19 to 55 seconds. A strong correlation was observed between wetting and disintegration times. Notably, formula F6, which had the shortest wetting time, also showed the fastest disintegration and drug release. After 10 minutes, F6 released nearly 100% of the drug content, outperforming other formulations and conventional film-coated tablets. This enhanced performance is attributed to its lower gelatin content. Conclusion: Tizanidine can be effectively formulated as a flash tablet, offering rapid disintegration and improved dissolution, potentially leading to faster onset of action and better patient compliance.
Recommended Citation
Fadhel, Ahmed Yousif and Younis, Yousif K.
()
"Preparation and In-Vitro Evaluation of Tizanidine Flash Oral Dispersible Tablet,"
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences: Vol. 4
:
Iss.
1
, Article 1.
Available at:
https://doi.org/10.62846/3006-5909.1038
