Synthesis and Characterization of Novel Derivatives of Imides 1,2,4-triazole Polymers via Microwave and Study Biological Activities

Authors

Bahaa Fadhil Hamzah, Anesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001 Babylon, IraqFollow

Abstract

New derivatives of imides 1,2,4-triazole polymers as pharmaceutical compounds were prepared from the synthesis of amic acid compounds (1A-E) by reacted of benzocaine with different cyclic anhydrides. Then cyclic imide compounds (2A-E), which prepared from converted amic acid compounds by using acetic anhydrate (CH₃CO)₂O and anhydrous sodium acetate CH₃COONa as a water drawer agent. Compounds (2A-E) were react with nucleophilic addition of hydrazine hydrate to ester cyclic imide compound to produce acid hydrazide cyclic imide compounds. Thereafter, cyclization of compounds (4A-E) and (5A-E) were prepared from react of acid hydrazide cyclic imide compounds with poly acryl amide via microwave to give imides 1,2,4-triazole polymers (4A-E) and in other path acid hydrazide cyclic imide react with poly acrylonitrile via microwave to give imides 1,2,4-triazole polymers (5A-E). All prepared compounds were characterization by physical properties such as melting point, softening point and analytic technique like FT-IR, ¹H-NMR for some of them, the compounds were tested anticancer and antibacterial applications were studied.

Recommended Citation

Hamzah, Bahaa Fadhil (2025) "Synthesis and Characterization of Novel Derivatives of Imides 1,2,4-triazole Polymers via Microwave and Study Biological Activities," Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences: Vol. 3 : Iss. 1 , Article 3.
Available at: https://doi.org/10.62846/3006-5909.1023