Abstract
Complexes containing Nickel, Copper, and Zinc salts were prepared and studied in this study. Additionally, novel Schiff Base ligands were synthesized by reacting 6-aminopenicillinic acid with benzoyl isothiocyanate to produce L. The synthesized ligand was evaluated by physical measures and spectroscopic methods such as Fourier transform infrared spectroscopy, nuclear magnetic resonance, ultraviolet-visible light, mass spectroscopy, and micro elemental analysis. Metal salts of (Ni(II), Cu(II), and Zn(II)) were combined with novel ligands at a molar ratio of 1:2 [M:L] to prepare the complexes. Spectroscopic, magnetic susceptibility, molar conductivity, atomic absorption, and DTA methods were used to study the complexes that were prepared. The β-lactam ring complexes exhibited coordination with the central metal ion through the N-atoms of the azomethine group and the O-atoms of the carbonyl group, leading to the formation of the resulting octahedral hybrid form, which was denoted as Sp3d2.Experiment on the biological activity of each ligand and its complexes against two bacterial species (S. aureus and P. pseudomonas), and find that all of them are more active than the starting materials.
Recommended Citation
AI-Janahi, Zaynab Faleh and Said, Mohammed Hamid
(2024)
"Preparation and Characterization Using a New Schiff Base Ligand Derived from Benzoyl Isothiocyanate with Their Complexes and Study of Their Biological Activity,"
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences: Vol. 2
:
Iss.
3
, Article 3.
Available at:
https://doi.org/10.62846/3006-5909.1018