Effect of Antibiotic Prophylaxis on Surgical Site Wound Infection in Third Molar Surgery: A Meta-Analysis

Authors

Mohamed Atif Elkholy, Lecturer of Prosthodontist at Ltuc Luminus Live Plus University at JordanFollow
Sayed Rashed Fashkal, Assistant professor of oral and maxillofacial at ltuc Luminus live plus university at Jordan AND Assistant professor of oral and maxillofacial surgery at al ahram alcandian university at Egypt

Abstract

The objective of this meta-analysis is to assess the impact of antibiotic prophylaxis (AP) on surgical site wound infection (SSWI) throughout third molar surgery (TMS).

A meta-analysis was conducted using examinations that compared AP to placebo for TMS from different languages that satisfied the inclusion criteria. Applying dichotomous random or fixed effect models, the findings of these studies were analysed, and the Odd Ratio (OR) was calculated with 95% confidence intervals (CIs).

A total of 18 studies conducted between 2001 and 2023 were included in the present analysis. These studies initially included 4063 individuals with TMS.

A substantial reduction in SSWI (OR, 0.46; 95% CI, 0.33-0.65, p

Data analysis showed that AP resulted in notably reduced SSWI compared to placebo in individuals with TMS. However, it is important to be cautious when dealing with its values due to the fact that the examinations were conducted by various surgeons with diverse expertise on different types of patients, and the small sample size of many of the examinations chosen for the meta-analysis.

Recommended Citation

Elkholy, Mohamed Atif and Fashkal, Sayed Rashed (2024) "Effect of Antibiotic Prophylaxis on Surgical Site Wound Infection in Third Molar Surgery: A Meta-Analysis," Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences: Vol. 2 : Iss. 2 , Article 4.
Available at: https://doi.org/10.62846/3006-5909.1013